Peplo · Reconstitution calculator

Tesofensine

metabolic

Tesofensine is taken orally — it is not reconstituted or drawn on a syringe.

Oral · capsule

Follow the product's own labeling for capsule strength and count. This is educational information, not medical advice.

A starting reference, not medical advice — see how we source this.

Half-life: ~220 h
Route: Oral
Storage: Oral formulation; not reconstituted (~30 days)
Citations: 2 referenced

US regulatory status

Not approved by the FDA for human use; sold and used as a research compound.

What is Tesofensine?

Tesofensine is a repurposed triple monoamine reuptake inhibitor, acting on dopamine, norepinephrine, and serotonin, that was developed in the context of obesity research. It is an oral capsule compound.

How Tesofensine works

Inhibits presynaptic reuptake of dopamine, norepinephrine, and serotonin, raising synaptic levels of all three. This central monoaminergic action suppresses appetite and increases energy expenditure, producing dose-related reductions in body weight, body fat, and waist circumference.

What the research says

Research has examined tesofensine as a monoamine reuptake inhibitor investigated for the treatment of obesity, including a Phase II program. One study looked at its effect on energy metabolism and appetite in overweight and moderately obese men. Reported Phase II data described dose-related reductions in body weight over a 24-week period. The literature characterizes its central monoaminergic action on appetite and energy expenditure.

Evidence limitations

The literature characterizes its central monoaminergic action rather than establishing approved clinical use.

Safety & use boundary

Tesofensine is a research compound and is not approved for human use. This information is educational and is not medical advice.

Published protocols

Dosing figures reported in the cited research. Educational reference, not a recommendation.

fat-loss
0.25–1 mg, once daily
2009 study

Using Tesofensine

New to this? Here's the whole process, start to finish. Educational only — not medical advice.

What you'll need

The Tesofensine capsules
A cool, dry spot to store them, out of direct light

How it's taken

Tesofensine is taken by mouth — there's no mixing and no syringe. Follow the product's own labeling for the capsule strength and how many to take. The calculators on this site are for injectable peptides, so you won't need one here.

Storing it

Tablets/capsules: store room temperature (15-30°C), dry, protected from light Keep the container closed and away from heat and light.

What “cycling” means

Many peptides are used in “cycles” — a stretch of daily or weekly use (“on”), then a break (“off”), rather than continuously. Cycling gives the body a rest and is a common pattern in the research. Any specific on/off lengths for a compound live in its published protocols above, drawn from the cited studies — this site shows you what the research used, it doesn't recommend a schedule for you.

Common first-timer mistakes

Shaking the vial to mix it
Swirl it gently or just let it sit. Shaking can damage delicate peptides — you want the powder to dissolve, not foam.
Using tap water or plain sterile water
Use bacteriostatic water. Plain sterile water has no preservative, so a mixed vial spoils in a day or two instead of lasting weeks.
Leaving a mixed vial on the counter
Keep reconstituted vials in the fridge. Heat and light break the peptide down faster.
Eyeballing the dose instead of measuring
Use the calculator and draw to the exact unit mark on the syringe. Guessing a tiny volume is where most measuring errors happen.
Reusing needles
Use a fresh syringe each time. A used needle is duller, hurts more, and is no longer sterile.
Mixing up mg and mcg
1 mg = 1000 mcg. The calculator keeps them straight so you don't have to — just enter your dose in the unit it asks for.

Words you'll see

Reconstitution: Mixing a freeze-dried peptide powder with liquid (bacteriostatic water) so it can be drawn into a syringe.
Bacteriostatic water: Sterile water with a tiny amount of benzyl alcohol that stops bacteria growing, so a mixed vial keeps for weeks. Not the same as plain sterile water.
U-100 insulin syringe: A small syringe marked in “units,” where 100 units = 1 mL. Peptide draws are measured in these units.
Subcutaneous (SubQ): An injection into the fatty layer just under the skin, rather than into muscle or a vein.
mcg vs mg: 1 mg = 1000 mcg. Doses are often written in micrograms (mcg); the calculator handles the conversion for you.
Lyophilized: Freeze-dried. The powder in the vial is the peptide with its water removed so it stays stable on the shelf.
Half-life: Roughly how long it takes your body to clear half of a dose — a rough sense of how long it stays active.

Common questions

What is Tesofensine?

Repurposed triple monoamine (dopamine, norepinephrine, serotonin) reuptake inhibitor developed for obesity. Phase II trials showed ~10% body-weight loss at 0.5 mg/day over 24 weeks. Oral capsule; not FDA-approved. Inhibits presynaptic reuptake of dopamine, norepinephrine, and serotonin, raising synaptic levels of all three. This central monoaminergic action suppresses appetite and increases energy expenditure, producing dose-related reductions in body weight, body fat, and waist circumference.

How is Tesofensine taken?

Tesofensine is taken orally (oral); it is not reconstituted or injected. Follow the product's own labeling; this is educational information, not medical advice.

What is the half-life of Tesofensine?

Research reports an approximate half-life of 220 hours for Tesofensine. Half-life informs how frequently a compound is studied; it is not a dosing instruction.

How should Tesofensine be stored?

Tablets/capsules: store room temperature (15-30°C), dry, protected from light Once reconstituted: Oral formulation; not reconstituted (about 30 days). This is general storage information, not medical advice.

Keep your protocol, doses, and vials in one place.

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