Peplo · Reconstitution calculator
MK-677 (Ibutamoren)
Orally bioavailable non-peptide ghrelin mimetic; produces sustained 24-hour elevation of GH and IGF-1.
growth-hormoneMK-677 (Ibutamoren) is taken orally — it is not reconstituted or drawn on a syringe.
Oral · capsule
Follow the product's own labeling for capsule strength and count. This is educational information, not medical advice.
A starting reference, not medical advice — see how we source this.
- Half-life
- ~24 h
- Route
- Oral
- Storage
- N/A — supplied as an oral solution or capsule (~365 days)
- Citations
- 2 referenced
US regulatory status
MK-677 is not approved as a therapeutic; it is a research compound, not an approved medicine.
What is MK-677 (Ibutamoren)?
MK-677 (Ibutamoren) is an orally bioavailable, non-peptide ghrelin mimetic — it is taken by mouth, not injected or reconstituted. It has been studied for its ability to produce a sustained elevation of growth hormone and IGF-1.
How MK-677 (Ibutamoren) works
Selectively activates the ghrelin/GHS-R1a receptor to amplify pulsatile GH release and elevate IGF-1.
What the research says
Clinical pharmacology studies have examined MK-677's effect on growth hormone and IGF-1 across 24-hour windows and its use in various research settings. See the references below.
Evidence limitations
This summary reflects the specific studies cited here and is not a complete account of the compound's clinical literature.
Safety & use boundary
MK-677 is a research compound, not an approved medicine. Research reports describe considerations such as effects on appetite, blood glucose, and fluid retention. Educational information only, not medical advice.
Published protocols
Dosing figures reported in the cited research. Educational reference, not a recommendation.
- 2008 study
sleep
10000–25000 mcg, once daily before sleep
- 1998 study
recovery
10000–25000 mcg, once daily
- 2008 study
longevity
10000–15000 mcg, once daily
- 2008 study
longevity
10000–15000 mcg, once daily
Using MK-677 (Ibutamoren)
New to this? Here's the whole process, start to finish. Educational only — not medical advice.
What you'll need
- The MK-677 (Ibutamoren) capsules
- A cool, dry spot to store them, out of direct light
How it's taken
MK-677 (Ibutamoren) is taken by mouth — there's no mixing and no syringe. Follow the product's own labeling for the capsule strength and how many to take. The calculators on this site are for injectable peptides, so you won't need one here.
Storing it
Room temperature; no reconstitution required Keep the container closed and away from heat and light.
What “cycling” means
Many peptides are used in “cycles” — a stretch of daily or weekly use (“on”), then a break (“off”), rather than continuously. Cycling gives the body a rest and is a common pattern in the research. Any specific on/off lengths for a compound live in its published protocols above, drawn from the cited studies — this site shows you what the research used, it doesn't recommend a schedule for you.
Common first-timer mistakes
Shaking the vial to mix it
Swirl it gently or just let it sit. Shaking can damage delicate peptides — you want the powder to dissolve, not foam.
Using tap water or plain sterile water
Use bacteriostatic water. Plain sterile water has no preservative, so a mixed vial spoils in a day or two instead of lasting weeks.
Leaving a mixed vial on the counter
Keep reconstituted vials in the fridge. Heat and light break the peptide down faster.
Eyeballing the dose instead of measuring
Use the calculator and draw to the exact unit mark on the syringe. Guessing a tiny volume is where most measuring errors happen.
Reusing needles
Use a fresh syringe each time. A used needle is duller, hurts more, and is no longer sterile.
Mixing up mg and mcg
1 mg = 1000 mcg. The calculator keeps them straight so you don't have to — just enter your dose in the unit it asks for.
Words you'll see
- Reconstitution
- Mixing a freeze-dried peptide powder with liquid (bacteriostatic water) so it can be drawn into a syringe.
- Bacteriostatic water
- Sterile water with a tiny amount of benzyl alcohol that stops bacteria growing, so a mixed vial keeps for weeks. Not the same as plain sterile water.
- U-100 insulin syringe
- A small syringe marked in “units,” where 100 units = 1 mL. Peptide draws are measured in these units.
- Subcutaneous (SubQ)
- An injection into the fatty layer just under the skin, rather than into muscle or a vein.
- mcg vs mg
- 1 mg = 1000 mcg. Doses are often written in micrograms (mcg); the calculator handles the conversion for you.
- Lyophilized
- Freeze-dried. The powder in the vial is the peptide with its water removed so it stays stable on the shelf.
- Half-life
- Roughly how long it takes your body to clear half of a dose — a rough sense of how long it stays active.
Common questions
What is MK-677 (Ibutamoren)?
Orally bioavailable non-peptide ghrelin mimetic; produces sustained 24-hour elevation of GH and IGF-1. Selectively activates the ghrelin/GHS-R1a receptor to amplify pulsatile GH release and elevate IGF-1.
How is MK-677 (Ibutamoren) taken?
MK-677 (Ibutamoren) is taken orally (oral); it is not reconstituted or injected. Follow the product's own labeling; this is educational information, not medical advice.
What is the half-life of MK-677 (Ibutamoren)?
Research reports an approximate half-life of 24 hours for MK-677 (Ibutamoren). Half-life informs how frequently a compound is studied; it is not a dosing instruction.
How should MK-677 (Ibutamoren) be stored?
Room temperature; no reconstitution required Once reconstituted: N/A — supplied as an oral solution or capsule (about 365 days). This is general storage information, not medical advice.
Keep your protocol, doses, and vials in one place.
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