Dihexa

Angiotensin IV-derived oligopeptide studied as a potent procognitive/synaptogenic agent via the HGF/c-Met system. Evidence is preclinical only; no human trials or established safety profile.

Cognitive

Dihexa is taken orally — it is not reconstituted or drawn on a syringe.

Oral · capsule

Follow the product's own labeling for capsule strength and count. This is educational information, not medical advice.

A starting reference, not medical advice — see how we source this.

Half-life: Not established
Route: Oral
Storage: Refrigerated 2-8°C; protect from light; use within ~30 days (~30 days)
Citations: 9 referenced

US regulatory status

Not approved for human use; handled as a research compound with no established human safety profile.

What is Dihexa?

Dihexa is an angiotensin IV-derived oligopeptide studied as a potent procognitive and synaptogenic agent through the HGF/c-Met system. Its mechanism involves binding hepatocyte growth factor and augmenting c-Met receptor activity.

How Dihexa works

Binds with high affinity to hepatocyte growth factor (HGF) and allosterically potentiates it, augmenting c-Met receptor phosphorylation at low HGF levels. This drives hippocampal spinogenesis and synaptogenesis linked to learning and memory in rodent models.

What the research says

Studies have examined how angiotensin IV-derived peptides produce procognitive and synaptogenic effects that depend on activation of the hepatocyte growth factor/c-Met system. Other research investigated hippocampal synaptogenesis and spatial memory using C-terminal truncated angiotensin IV analogs, and evaluated metabolically stabilized analogs as candidate procognitive agents. Related work explored small-molecule angiotensin IV analogs in the context of Alzheimer's and Parkinson's disease models, along with HGF-mimetic effects in other cellular systems.

Evidence limitations

Reported evidence is preclinical only, with no human trials or established safety profile. This evidence is confined to preclinical and rodent-model investigation, with no established human data.

Safety & use boundary

Dihexa is a research compound with no established human safety profile and is not approved for human use. This information is educational and is not medical advice.

Using Dihexa

New to this? Here's the whole process, start to finish. Educational only — not medical advice.

What you'll need

The Dihexa capsules
A cool, dry spot to store them, out of direct light

How it's taken

Dihexa is taken by mouth — there's no mixing and no syringe. Follow the product's own labeling for the capsule strength and how many to take. The calculators on this site are for injectable peptides, so you won't need one here.

Storing it

Lyophilized powder/capsules: store at -20°C, protected from light and moisture Keep the container closed and away from heat and light.

Common first-timer mistakes

Shaking the vial to mix it
Swirl it gently or just let it sit. Shaking can damage delicate peptides — you want the powder to dissolve, not foam.
Using tap water or plain sterile water
Use bacteriostatic water. Plain sterile water has no preservative, so a mixed vial spoils in a day or two instead of lasting weeks.
Leaving a mixed vial on the counter
Keep reconstituted vials in the fridge. Heat and light break the peptide down faster.
Eyeballing the dose instead of measuring
Use the calculator and draw to the exact unit mark on the syringe. Guessing a tiny volume is where most measuring errors happen.
Reusing needles
Use a fresh syringe each time. A used needle is duller, hurts more, and is no longer sterile.
Mixing up mg and mcg
1 mg = 1000 mcg. The calculator keeps them straight so you don't have to — just enter your dose in the unit it asks for.

Words you'll see

Reconstitution: Mixing a freeze-dried peptide powder with liquid (bacteriostatic water) so it can be drawn into a syringe.
Bacteriostatic water: Sterile water with a tiny amount of benzyl alcohol that stops bacteria growing, so a mixed vial keeps for weeks. Not the same as plain sterile water.
U-100 insulin syringe: A small syringe marked in “units,” where 100 units = 1 mL. Peptide draws are measured in these units.
Subcutaneous (SubQ): An injection into the fatty layer just under the skin, rather than into muscle or a vein.
mcg vs mg: 1 mg = 1000 mcg. Doses are often written in micrograms (mcg); the calculator handles the conversion for you.
Lyophilized: Freeze-dried. The powder in the vial is the peptide with its water removed so it stays stable on the shelf.
Half-life: Roughly how long it takes your body to clear half of a dose — a rough sense of how long it stays active.

Common questions

What is Dihexa?

Angiotensin IV-derived oligopeptide studied as a potent procognitive/synaptogenic agent via the HGF/c-Met system. Evidence is preclinical only; no human trials or established safety profile. Binds with high affinity to hepatocyte growth factor (HGF) and allosterically potentiates it, augmenting c-Met receptor phosphorylation at low HGF levels. This drives hippocampal spinogenesis and synaptogenesis linked to learning and memory in rodent models.

How is Dihexa taken?

Dihexa is taken orally (oral); it is not reconstituted or injected. Follow the product's own labeling; this is educational information, not medical advice.

How should Dihexa be stored?

Lyophilized powder/capsules: store at -20°C, protected from light and moisture Once reconstituted: Refrigerated 2-8°C; protect from light; use within ~30 days (about 30 days). This is general storage information, not medical advice.

Keep your protocol, doses, and vials in one place.

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