Peplo · Reconstitution calculator

5-Amino-1MQ

Small-molecule NNMT inhibitor studied for fat loss and metabolic effects; raises intracellular NAD+ and suppresses adipocyte lipogenesis. Evidence is preclinical (mouse/cell) only. Typically sold as oral capsules.

metabolic

5-Amino-1MQ is taken orally — it is not reconstituted or drawn on a syringe.

Oral · capsule

Follow the product's own labeling for capsule strength and count. This is educational information, not medical advice.

A starting reference, not medical advice — see how we source this.

Half-life: Not established
Route: Oral
Storage: If dissolved for research, refrigerate 2-8°C and protect from light (~30 days)
Citations: 9 referenced

US regulatory status

Not approved by the FDA for human use; sold and used as a research compound.

What is 5-Amino-1MQ?

5-Amino-1MQ is a small molecule that acts as an inhibitor of the enzyme nicotinamide N-methyltransferase (NNMT), typically sold as oral capsules. It has been studied in the context of fat loss and metabolic effects, where research describes it raising intracellular NAD+ and suppressing fat-cell lipogenesis.

How 5-Amino-1MQ works

Binds nicotinamide N-methyltransferase (NNMT), slowing methylation of nicotinamide to 1-methylnicotinamide. This preserves the NAD+ precursor pool and methyl-donor economy, raising intracellular NAD+, suppressing lipogenesis, and improving insulin sensitivity in diet-induced obese mice.

What the research says

Studies have examined NNMT knockdown in the setting of diet-induced obesity, the structure-activity relationship of small-molecule NNMT inhibitors, and how membrane-permeable inhibitors were investigated in high-fat-diet obese mice. Other reports looked at effects on senescent muscle stem cells and aged skeletal muscle, and at combining NNMT inhibition with a reduced-calorie diet in obese mice. A separate pharmacokinetic paper described an assay for measuring the compound in rat plasma.

Evidence limitations

The available literature centers on preclinical work in mice and cell models rather than human trials, and the human or clinical evidence remains limited.

Safety & use boundary

5-Amino-1MQ is a research compound whose data comes from animal and laboratory studies, not established human safety trials. This page is educational information and is not medical advice; anyone considering it should consult a qualified clinician.

Published protocols

Dosing figures reported in the cited research. Educational reference, not a recommendation.

fat-loss
50–150 mg, once daily
2014 study

Using 5-Amino-1MQ

New to this? Here's the whole process, start to finish. Educational only — not medical advice.

What you'll need

The 5-Amino-1MQ capsules
A cool, dry spot to store them, out of direct light

How it's taken

5-Amino-1MQ is taken by mouth — there's no mixing and no syringe. Follow the product's own labeling for the capsule strength and how many to take. The calculators on this site are for injectable peptides, so you won't need one here.

Storing it

Capsules/powder: store room temperature, cool, dry, desiccated, away from light Keep the container closed and away from heat and light.

What “cycling” means

Many peptides are used in “cycles” — a stretch of daily or weekly use (“on”), then a break (“off”), rather than continuously. Cycling gives the body a rest and is a common pattern in the research. Any specific on/off lengths for a compound live in its published protocols above, drawn from the cited studies — this site shows you what the research used, it doesn't recommend a schedule for you.

Common first-timer mistakes

Shaking the vial to mix it
Swirl it gently or just let it sit. Shaking can damage delicate peptides — you want the powder to dissolve, not foam.
Using tap water or plain sterile water
Use bacteriostatic water. Plain sterile water has no preservative, so a mixed vial spoils in a day or two instead of lasting weeks.
Leaving a mixed vial on the counter
Keep reconstituted vials in the fridge. Heat and light break the peptide down faster.
Eyeballing the dose instead of measuring
Use the calculator and draw to the exact unit mark on the syringe. Guessing a tiny volume is where most measuring errors happen.
Reusing needles
Use a fresh syringe each time. A used needle is duller, hurts more, and is no longer sterile.
Mixing up mg and mcg
1 mg = 1000 mcg. The calculator keeps them straight so you don't have to — just enter your dose in the unit it asks for.

Words you'll see

Reconstitution: Mixing a freeze-dried peptide powder with liquid (bacteriostatic water) so it can be drawn into a syringe.
Bacteriostatic water: Sterile water with a tiny amount of benzyl alcohol that stops bacteria growing, so a mixed vial keeps for weeks. Not the same as plain sterile water.
U-100 insulin syringe: A small syringe marked in “units,” where 100 units = 1 mL. Peptide draws are measured in these units.
Subcutaneous (SubQ): An injection into the fatty layer just under the skin, rather than into muscle or a vein.
mcg vs mg: 1 mg = 1000 mcg. Doses are often written in micrograms (mcg); the calculator handles the conversion for you.
Lyophilized: Freeze-dried. The powder in the vial is the peptide with its water removed so it stays stable on the shelf.
Half-life: Roughly how long it takes your body to clear half of a dose — a rough sense of how long it stays active.

Common questions

What is 5-Amino-1MQ?

Small-molecule NNMT inhibitor studied for fat loss and metabolic effects; raises intracellular NAD+ and suppresses adipocyte lipogenesis. Evidence is preclinical (mouse/cell) only. Typically sold as oral capsules. Binds nicotinamide N-methyltransferase (NNMT), slowing methylation of nicotinamide to 1-methylnicotinamide. This preserves the NAD+ precursor pool and methyl-donor economy, raising intracellular NAD+, suppressing lipogenesis, and improving insulin sensitivity in diet-induced obese mice.

How is 5-Amino-1MQ taken?

5-Amino-1MQ is taken orally (oral); it is not reconstituted or injected. Follow the product's own labeling; this is educational information, not medical advice.

How should 5-Amino-1MQ be stored?

Capsules/powder: store room temperature, cool, dry, desiccated, away from light Once reconstituted: If dissolved for research, refrigerate 2-8°C and protect from light (about 30 days). This is general storage information, not medical advice.

Keep your protocol, doses, and vials in one place.

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